Mahyar A. Nouri-Shirazi, Ph.D.

Biography

Mahyar Nouri-Shirazi, D.V.M., Ph.D., is a Professor of Immunology in the Department of Medicine at the Charles E. Schmidt College of Medicine at Florida Atlantic University. Dr. Nouri-Shirazi is an immunologist with a keen interest in immunotherapy and vaccines. He has contributed to the field of cancer immunotherapy by designing dendritic cell (DC)-based vaccines for patients with cancer, as well as to the field of transplant immunology through pharmacologically modified DC-based vaccines for tolerance induction. His research lab has also studied the possibility of refining the immune response to vaccines in individuals with compromised immune systems using Toll-like receptor (TLR) agonists. Among his educational responsibilities, he teaches Immunology to M1 and M2 medical and graduate students, and he serves as the director of the M2 Pathophysiology and Therapeutics 4 course.

Education

• 1992 D.V.M., Tottori University, School of Veterinary Medicine, Japan
• 1996 Ph.D., Chiba University, School of Medicine, Japan

Work History

• 2024-present Interim Associate Dean of Faculty Affairs, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2017-present Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2011-2017 Associate Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2008-2011 Assistant Professor, Charles E. Schmidt College of Medicine, Florida Atlantic University
• 2008-2011 Affiliated Assistant Professor of Microbiology & Immunology, University of Miami Miller School of Medicine
• 2005-2008 Adjunct Assistant Professor, Baylor University, Texas
• 2001-2008 Assistant Professor, Texas A&M University System Health Science center, Baylor College of Dentistry, Texas
• 1998-2001 Senior Research Scientist Fellow, Baylor Institute for Immunology Research, Texas
• 1996-1998 Research Scientist, Bayer Pharmaceutical Ltd, Research Center Kyoto, Division of Autoimmunity. Kyoto, Japan
• 1994-1996 Research Scientist, Columbia University, College of Physician and Surgeons, Department of Microbiology. New York, NY

Scholarly Activity

Selected Peer-Reviewed Publications

• Czdari Lee, Imtisal Imran, Sara Thomas, and Mahyar Nouri-Shirazi. A comprehensive method for the phenotypical and functional characterization of recalled human memory B and T cells specific to vaccine antigens. Journal of Immunological Methods. 2024 February 527
• Nouri-Shirazi M, Guinet E. TLR3 and TLR7/8 agonists improve immunization outcome in nicotine exposed mice through different mechanisms. Immunology Letters. 2022 Jun; 246:18-26.
• Zhou J, Nouri-Shirazi M, Tang H, Shen Y, Zeng M. R848/TLR7-Mediated Stronger CD8+ T Immunity Is Dependent on DC-NK Cell Interactions. International Archives of Allergy and Immunology. 2022 Mar 9:1-16.
• Katz H, Victor L, Guinet E, Nouri-Shirazi M. Human T cells show plasticity for direct recognition of xenogeneic dendritic cells. Immunology Letters. 2022 August: 248: 90-95
• Nouri-Shirazi M, Tamjidi S, Nourishirazi E, and Elisabeth Guinet. Combination of TLR8 and TLR4 agonists reduces the degrading effects of nicotine on DC-NK mediated effector T cell generation. INTERNATIONAL IMMUNOPHARMACOLOGY 61 (2018) 54-63
• Nouri-Shirazi M, Tamjidi S, Nourishirazi E, and Elisabeth Guinet. TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells. IMMUNOLOGY LETTERS 193 (2018) 58-66
• Zeng M, Nourishirazi E, Guinet E, and Nouri-Shirazi M. Genetic background influences the cellular and humoral immune responses to vaccines. CLINICAL AND EXPERIMENTAL IMMUNOLOGY Volume: 186 Issue: 2 Pages 190–204 Nov 2016
• Nouri-Shirazi, C. Kahlden, P. Nishino, and E. Guinet. Nicotine Exposure Alters the mRNA Expression of Notch Ligands in Dendritic Cells and Their Response to Th1-/Th2-Promoting Stimuli. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81(2): 110-120 FEB 2015
• Nouri-Shirazi M and Guinet E. Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination. THE JOURNAL OF IMMUNOLOGY 188 (5): 2359-70 MAR 2012
• Kogiso M, Nishiyama A, Shinohara T, Nakamura M, Mizoguchi E, Misawa Y, Guinet E, Nouri-Shirazi M, Dorey CK, Henriksen RA, Shibata Y. Chitin particles induce size-dependent but carbohydrate-independent innate eosinophilia. JOURNAL OF LEUKOCYTE BIOLOGY 90 (1): 167-76 JUL 2011
• Zeng MH, Guinet E, Nouri-Shirazi M. Comparative analysis of dendritic cells and anti-CD3/CD8 expanded regulatory T cells for application in transplantation. TRANSPLANT IMMUNOLOGY 22 (1-2): 82-92 2009
• Zeng M, Guinet E, Nouri-Shirazi M. B7-1 and B7-2 differentially control peripheral homeostasis of CD4(+)CD25(+)Foxp3(+) regulatory T cells. TRANSPLANT IMMUNOLOGY 20 (3): 171-179 2009
• Nouri-Shirazi M, Zeng MH, Guinet E. Dendritic cells and anti-CD3/CD28 expand naturally occurring regulatory T cells with different magnitude and nature. AMERICAN JOURNAL OF TRANSPLANTATION 8: 418-418 2008
• Nouri-Shirazi M, Tinajero R, Guinet E. Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs). IMMUNOLOGY LETTERS 109 (2): 155-164 APR 15 2007
• Nouri-Shirazi M, Guinet E. A possible mechanism linking cigarette smoke to higher incidence of respiratory infection and asthma. IMMUNOLOGY LETTERS 103 (2): 167-176 MAR 15 2006
• Guinet E, Yoshida K, Nouri-Shirazi M. Nicotinic environment affects the differentiation and functional maturation of monocytes derived dendritic cells (DCs). IMMUNOLOGY LETTERS 95 (1): 45-55 AUG 15 2004
• Nouri-Shirazi M, Guinet E. Evidence for the immunosuppressive role of nicotine on human dendritic cell functions. IMMUNOLOGY 109 (3): 365-373 JUL 2003
• Berard F, Blanco P, Davoust J, Neidhart-Berard E, Nouri-Shirazi M, Taquet N, Rimoldi D, Cerottini JC, Banchereau J, Palucka AK. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. JOURNAL OF EXPERIMENTAL MEDICINE 192 (11): 1535-1543 DEC 4 2000
• Nouri-Shirazi M, Banchereau J, Bell D, Burkeholder S, Kraus ET, Davoust J, Palucka KA. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. JOURNAL OF IMMUNOLOGY 165 (7): 3797-3803 OCT 1 2000
• Ye BH, Cattoretti G, Shen QO, Zhang JD, Hawe N, deWaard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RSK, Rothman P, Stall AM, Pandolfi PP, DallaFavera R. The BCL-6 proto-oncogene controls germinal-center formation and Th2-type inflammation. NATURE GENETICS 16 (2): 161-170 JUN 1997
• Yamamoto H, Hatano M, Iitsuka Y, Nouri-Shirazi M, Yamamoto M, Tokuhisa T. Two forms of HOX11, a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes. MOLECULAR IMMUNOLOGY 32 (16): 1177-1182 NOV 1995

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Honors and Awards

• 2024 Distinguished Mentor of the Year Award: Excellence in Undergraduate Research and Inquiry Mentorship, Florida Atlantic University
• 2022 Outstanding Problem-Based Learning (PBL) Facilitator Award, Charles E. Schmidt College of Medicine
• 2019 Outstanding Course Director Award, Charles E. Schmidt College of Medicine
• 2016 AAI Travel Award, International Congress of Immunology
• 2015 AAI Laboratory Travel Award, The American Association of Immunologists
• 2014 AAI Laboratory Travel Award, The American Association of Immunologists
• 2013 Outstanding Problem-Based Learning (PBL) Facilitator Award, Charles E. Schmidt College of Medicine
• 2012 Researcher Excellence Award, American Association for Laboratory Animal Science
• 2012 AAI Laboratory Travel Award, The American Association of Immunologists
• 2011 Dwight W. Warren Award for Excellence in Graduate Teaching, Florida Atlantic University- Charles E. Schmidt College of Medicine
• 2007 Basic Science Faculty Research Award, Texas A&M University Health Science Center-Baylor College of Dentistry

Research funding

• Principal Investigator: NIH-NIAID 1R03AI103750-01A1
• Principal Investigator: Georgia Aquarium180288
• Principal Investigator: Phillip Morris Inc,. USA
• Mentor: Natural Science Foundation of China (NSFC)
• Mentor: NIH-NIDCR K23 DE00-469-01
• Collaborator: NIH-NINDS 1R15NS066339
• Co-investigator: CaPCURE
• Senior Scientist: NIH-NIAID R01CA78846-01A1

Patent

• Inventor: US file patent number 60/159,903
• Inventor: US file patent number US10/110,553
• Inventor: US Provisional patent #61/596,919

Editorial and Professional Affiliations

• Member: American Association of Immunologists (AAI)
• Member: Society of Leucocyte Biology (SLB)
• Editorial Board: Frontiers Immunology Journal